Abstract: Multivariate Analysis of Prognostic Factors of Endometrial Carcinoma by COX ProportionalHazard Regression ModelMinWANG, Zhihong MA,Chunxue SHICorrespondence to: MinWANG, E-mail: wm21st@126.comDepartment of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang 110004, ChinaAbstract Objective: To evaluate various clinical characteristics ( menopause, clinical and surgical surgical stage, histologicalgrade, myometrial invasion, lymph node transmission, pathological stage and adjuvant therapy ) and biological factors ( ER, PR,COX-2, VEGF and KDR expression ) for prognosis of endometrial carcinoma, and to analyze the clinical characteristics and biologicalfactors by univariate and multivariate analysis in order to comprehensively evaluate the effect of clinical and biological factors on endo-metrial carcinoma and select the most significant factor for prognosis. Methods: The clinical and biological factors were analyzed byunivariate analysis and multivariate analysis through COX proportional hazard regression model. Results: One hundred thirty-seven en-dometrial carcinoma cases were investigated, and 112 were followed-up successfully. The five-year survival rate was 83.04%. Thefive-year survival rates of stage Ⅰto Ⅳ were 89.66%, 80%, 53.85%, and 0%, respectively. The expression rates were 47.32% forCOX-2, 66.07% for VEGF and 52.68% for KDR. The five-year accumulated survival rate was 75.47% for endometrial carcinoma withdetectable COX-2 expression, 78.38% for endometrial carcinoma with detectable VEGF, and 72.88% for endometrial carcinoma withdetectable KDR expression. By analyzing the 7 clinical factors and 5 biological factors through univariate analysis, the clinical and sur-gical stage, myometrial invasion, histological grade, lymph node transmission, COX-2 positive status, KDR positive status, ER positivestatus, and PR positive status were associated with prognosis ( P < 0.05 ), while menopause, pathological stage, adjuvant therapy andVEGF positive status were not associated with prognosis ( P > 0.05 ). These 8 factors were analyzed by Cox proportional hazard regres-sion model analysis. Myometrial invasion, operate period, and histological grade were the most important factors for endometrial carci-noma prognosis. Conclusion: According to analysis by Cox proportional hazard regression model, myometrial invasion, operate period,and histological grade are the most important factors for endometrial carcinoma prognosis. These findings are significant for those for-mulating a prognosis and for the systematic treatment of endometrial carcinoma.Keywords Endometrial carcinoma; Clinical pathological and biological factors; Prognosis;COX proportional hazard regression model